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Saint Louis University

Post Doctoral Fellow

1100 South Grand Blvd; St. Louis, MO 63104

Paid (based on experience)

In person

About the Company

About the Role

NIH funded postdoctoral positions are available to study the structural enzymology of proteins responsible for blood coagulation (https://biochem.slu.edu/faculty/dicerawp/) with the goal of unraveling the molecular architecture and mechanism of the underlying interactions. The approach uses a combination of conventional (rapid kinetics, protein engineering, X-ray crystallography) and innovative (smFRET, cryo-EM) biophysical techniques. Current projects in the lab focus on the interaction of prothrombin with prothrombinase, leading to generation of thrombin and blood clotting, the activation of factor V required for assembly of prothrombinase and the interaction of the thrombin-thrombomodulin complex with protein C that halts the coagulation response. Additional studies focus on factor V short and its interactions with TFPIalpha, protein S and factor Xa and on proteins of the contact pathway like factors IX, XI and XII. Experience in rapid kinetics, smFRET, X-ray crystallography, NMR, or cryoEM is required.

Start Date

5/13/2024

Requirements

Hours

40

Compensation

Paid (based on experience)

Website

How to Apply

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