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Saint Louis University

Post Doctoral Fellow

1100 S Grand Blvd, St. Louis, MO 63104, USA

Based on experience

Paid

About the Company

Saint Louis University is a private Jesuit research university.

About the Role

NIH funded postdoctoral positions are available to study the structural enzymology of proteins responsible for blood coagulation (https://biochem.slu.edu/faculty/dicerawp/) with the goal of unraveling the molecular architecture and mechanism of the underlying interactions. The approach uses a combination of conventional (rapid kinetics, protein engineering, X-ray crystallography) and innovative (smFRET, cryo-EM) biophysical techniques. Current projects in the lab focus on the interaction of prothrombin with prothrombinase, leading to generation of thrombin and blood clotting, the activation of factor V required for assembly of prothrombinase and the interaction of the thrombin-thrombomodulin complex with protein C that halts the coagulation response. Additional studies focus on factor V short and its interactions with TFPIalpha, protein S and factor Xa and on proteins of the contact pathway like factors IX, XI and XII. Experience in rapid kinetics, smFRET, X-ray crystallography, NMR, or cryoEM is required.

Start Date

5/13/2024

Requirements

For questions, contact lachina.mccoy@health.slu.edu

Hours

40 hours/week

Compensation

Based on experience

Website

How to Apply

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